{"id":9625,"date":"2021-06-17T10:45:00","date_gmt":"2021-06-17T08:45:00","guid":{"rendered":"https:\/\/www.new.pbkm.pl\/pregnancy-zone-2\/%pregnancy_zone_category%\/cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee"},"modified":"2024-07-31T14:15:42","modified_gmt":"2024-07-31T12:15:42","slug":"cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee","status":"publish","type":"pregnancy_zone","link":"https:\/\/www.pbkm.pl\/en\/pregnancy-zone-2\/good-to-know\/cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee","title":{"rendered":"Cord blood transplantation in Polish pediatric centers: a report by the Polish Pediatric Blood Transplantation Group. Blood Cell Transplantation Committee"},"content":{"rendered":"\n

Przeszczepianie kom\u00f3rek krwiotw\u00f3rczych krwi p\u0119powinowej (CBT) jest uznan\u0105 metod\u0105 terapeutyczn\u0105, wykonywan\u0105 od roku 1988. Pierwsze przeszczepienie w Polsce wy\u0142\u0105cznie z krwi p\u0119powinowej wyko\u00adnano 12 pa\u017adziernika 2000 r. w Poznaniu.<\/p>\n\n\n\n

Cel pracy: Analiza wynik\u00f3w przeszczepiania kom\u00f3rek krwiotw\u00f3rczych w polskich o\u015brodkach pediatrycznych.<\/p>\n\n\n\n

Pacjenci i metodyka: Do bada\u0144 w\u0142\u0105czono 19 pacjent\u00f3w (5 dziewcz\u0105t, 14 ch\u0142opc\u00f3w), w wieku 0,1\u201310 lat (mediana 4,3 roku), u kt\u00f3rych w la\u00adtach 2000\u20132011 w polskich o\u015brodkach pediatrycznych wykonano prze\u00adszczepienie krwi p\u0119powinowej. Pacjent\u00f3w kierowano do CBT z powodu nast\u0119puj\u0105cych rozpozna\u0144: ostra bia\u0142aczka limfoblastyczna (n=6), ostra bia\u0142aczka mieloblastyczna (n=1), zesp\u00f3\u0142 mielodysplastyczny (n=2), ze\u00adsp\u00f3\u0142 Wiskotta i Aldricha (n=3), niedokrwisto\u015b\u0107 Fanconiego (n=2), ad\u00adrenoleukodystrofia (n=1), histiocytoza Langerhansa (n=1), przewlek\u0142a choroba ziarniniakowa (n=1), zesp\u00f3\u0142 Kostmanna (n=1), zesp\u00f3\u0142 Sandhof\u00adfa (n=1). Zastosowano kondycjonowanie mieloablacyjne u 9 pacjent\u00f3w oraz o zredukowanej toksyczno\u015bci u 10 pacjent\u00f3w. Krew p\u0119powino\u00adwa pochodzi\u0142a od dawcy rodzinnego w 8 przypadkach lub od dawcy niespokrewnionego w 11 przypadkach. Zgodno\u015b\u0107 6\/6 HLA wyst\u0105pi\u0142a w 10 przypadkach.<\/p>\n\n\n\n

Wyniki: 10\/19 (52,6%) dzieci \u017cyje, mediana prze\u017cycia 3,1 roku (95%CI=1,4\u20134,7), prawdopodobie\u0144stwo prze\u017cycia 2-letniego wynosi 0,409\u00b10,133. Przyczyny zgon\u00f3w obejmowa\u0142y brak przyj\u0119cia przeszcze\u00adpu (n=2), powik\u0142ania infekcyjne (n=3) lub wznow\u0119 (n=4). Dwoje dzieci z powodu nieprzyj\u0119cia przeszczepu mia\u0142o wykonane przeszczepienie ha\u00adploidentyczne. W analizie wielowariantowej, jedynym czynnikiem pro\u00adgnostycznym maj\u0105cym wp\u0142yw na ca\u0142kowite prze\u017cycie by\u0142o wyst\u0105pienie udokumentowanego uog\u00f3lnionego zaka\u017cenia do dnia +180.<\/p>\n\n\n\n

Wnioski: U pacjent\u00f3w niemaj\u0105cych zgodnego dawcy CBT jest wa\u017cn\u0105 opcj\u0105 terapeutyczn\u0105, daj\u0105c\u0105 szanse wyleczenia dla oko\u0142o po\u0142owy pa\u00adcjent\u00f3w.<\/p>\n\n\n\n

Publikacja:\u00a0za\u0142\u0105cznik<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Przeszczepianie kom\u00f3rek krwiotw\u00f3rczych krwi p\u0119powinowej (CBT) jest uznan\u0105 metod\u0105 terapeutyczn\u0105, wykonywan\u0105 od roku 1988. Pierwsze przeszczepienie w Polsce wy\u0142\u0105cznie z krwi p\u0119powinowej wyko\u00adnano 12 pa\u017adziernika 2000 r. w Poznaniu. Cel pracy: Analiza wynik\u00f3w przeszczepiania kom\u00f3rek krwiotw\u00f3rczych w polskich o\u015brodkach pediatrycznych. Pacjenci i metodyka: Do bada\u0144 w\u0142\u0105czono 19 pacjent\u00f3w (5 dziewcz\u0105t, 14 ch\u0142opc\u00f3w), w wieku 0,1\u201310 lat (mediana 4,3 roku), u kt\u00f3rych w la\u00adtach […]<\/p>\n","protected":false},"author":1,"featured_media":8375,"template":"","pregnancy_zone_category":[75],"class_list":["post-9625","pregnancy_zone","type-pregnancy_zone","status-publish","has-post-thumbnail","hentry","pregnancy_zone_category-good-to-know"],"yoast_head":"\nCord blood transplantation in Polish pediatric centers: a report by the Polish Pediatric Blood Transplantation Group. 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Pierwsze przeszczepienie w Polsce wy\u0142\u0105cznie z krwi p\u0119powinowej wyko\u00adnano 12 pa\u017adziernika 2000 r. w Poznaniu. Cel pracy: Analiza wynik\u00f3w przeszczepiania kom\u00f3rek krwiotw\u00f3rczych w polskich o\u015brodkach pediatrycznych. Pacjenci i metodyka: Do bada\u0144 w\u0142\u0105czono 19 pacjent\u00f3w (5 dziewcz\u0105t, 14 ch\u0142opc\u00f3w), w wieku 0,1\u201310 lat (mediana 4,3 roku), u kt\u00f3rych w la\u00adtach […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pbkm.pl\/en\/pregnancy-zone-2\/good-to-know\/cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee\" \/>\n<meta property=\"og:site_name\" content=\"PBKM\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-31T12:15:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.pbkm.pl\/wp-content\/uploads\/2024\/07\/Background4.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"558\" \/>\n\t<meta property=\"og:image:height\" content=\"325\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.pbkm.pl\\\/en\\\/pregnancy-zone-2\\\/good-to-know\\\/cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee\",\"url\":\"https:\\\/\\\/www.pbkm.pl\\\/en\\\/pregnancy-zone-2\\\/good-to-know\\\/cord-blood-transplantation-in-polish-pediatric-centers-a-report-by-the-polish-pediatric-blood-transplantation-group-blood-cell-transplantation-committee\",\"name\":\"Cord blood transplantation in Polish pediatric centers: a report by the Polish Pediatric Blood Transplantation Group. 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